The nervous system is vital to the body’s information processing capacity, including cognition as well as basic life-sustaining functions. The structure and function of the cells and tissues that comprise the nervous system are very tightly linked, and these structures and organization help ensure proper functioning. This organization and structure, both on a large-scale and cellular level, is disrupted in neurological and neurodegenerative conditions, such as ALS and multiple sclerosis. In this lesson, students will learn the structure-function relationships and key disease mechanisms by first constructing neuronal models, then playing a quick game to demonstrate the importance of myelination.